Maserati participated in Grand Prix racing during the 1930s and in Formula One motor racing during the 1950s and 1960s. Its works Formula One programme was broadly successful, providing a total of 9 Grand Prix wins for the factory team. In addition, Juan Manuel Fangio won the 1957 World Championship of Drivers with a Maserati 250F.

Maserati designed two Formula One cars: the Maserati 4CLT and the Maserati 250F, and the pre-World War II Maserati 4CL was also used with some success. In addition, the Maserati A6GCM, designed as a Formula Two car, was also used in F1. Due to financial difficulties in the late 1950s the team had to withdraw from Formula One in 1958 despite the 250F still being successful. Privateers continued to use the 250F until 1960.

In the 1960s, Maserati supplied engines to British Formula One team Cooper as well as a number of smaller teams. The most successful car of that collaboration was the Cooper-Maserati T81, which had a Maserati V12 engine. It won the 1966 Mexican Grand Prix and the 1967 South African Grand Prix, driven by John Surtees and Pedro Rodríguez respectively.

Activity: 1950 - 1960
Grand Prix: 77
Constructor Championships: *

Drivers Championships: 2
Victories: 9
Pole Positions: 10
Fastest Laps: 15
Championship Points: *

*From 1950 to 1957 there was no Constructors' Championship.